A Codon-Based Model of Nucleotide Substitution for Protein-Coding DNA Sequences.

Goldman, N., & Yang, Z. (1994). A Codon-Based Model of Nucleotide Substitution for Protein-Coding DNA Sequences. Molecular Biology and Evolution, 11(5), 725-736.

Type

Journal article

Intellectual base

Primary research

Year

1994

DOI

10.1093/oxfordjournals.molbev.a040153

Link

https://doi.org/10.1093/oxfordjournals.molbev.a040153

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Domain-specific

• Ka/Ks ratio
  • A ratio alone does not establish adaptive function; sound use requires appropriate codon models, uncertainty, and phylogenetic or population-genetic context.
• Substitution Model
  • Jukes–Cantor, Kimura two-parameter, Felsenstein 1981, HKY, GTR, empirical amino-acid matrices, codon models, and the Mk model for morphology are instances with different alphabets and constraints.

    This sourceDefines a Markov codon model with transition bias, codon usage, and protein-level constraint.

Verification

This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.

Registry ID ref:3c8b020ab8d7 · see in the full table