What is synergy¶
Berenbaum, M. C. (1989). What is synergy. Pharmacological Reviews, 41(2), 93-141.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Potentiation
- As Berenbaum (1989) articulates in his foundational analysis of combined-drug effects, a complete potentiation description specifies: (1) the primary agent or stimulus being potentiated; (2) the sensitizing condition—a prior dose, concurrent co-exposure, priming stimulus, or adaptive internal state; (3) the mechanism—receptor up-regulation, increased signal-transduction gain, synaptic structural changes (AMPA receptor insertion in long-term potentiation), immune memory expansion, or pharmacokinetic pathway saturation reducing clearance; and (4) the temporal trajectory—acute (seconds to minutes), short-term (minutes to hours), or long-term (hours to lifetime persistence).
This sourceCanonical analysis arguing that any claim of synergy or antagonism is meaningful only relative to an explicitly specified null model of interaction (typically Loewe additivity or Bliss independence); foundational for the testability requirement.
- As Berenbaum (1989) articulates in his foundational analysis of combined-drug effects, a complete potentiation description specifies: (1) the primary agent or stimulus being potentiated; (2) the sensitizing condition—a prior dose, concurrent co-exposure, priming stimulus, or adaptive internal state; (3) the mechanism—receptor up-regulation, increased signal-transduction gain, synaptic structural changes (AMPA receptor insertion in long-term potentiation), immune memory expansion, or pharmacokinetic pathway saturation reducing clearance; and (4) the temporal trajectory—acute (seconds to minutes), short-term (minutes to hours), or long-term (hours to lifetime persistence).
- Synergy and Antagonism
- The construct is clarifying because it forces explicit specification of a baseline model without which "combined effect" statements are uninterpretable, as Berenbaum (1989) argued in his canonical analysis of what synergy actually means.
This sourceCanonical analysis arguing that any claim of synergy or antagonism is meaningful only relative to an explicitly specified null model of interaction (typically Loewe additivity or Bliss independence); foundational for the testability requirement.
- The construct is clarifying because it forces explicit specification of a baseline model without which "combined effect" statements are uninterpretable, as Berenbaum (1989) argued in his canonical analysis of what synergy actually means.
Verification¶
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Does it back the claim? Not recorded. Neither this nor any other of the 2 citations of this work carries a recorded support check.
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Registry ID ref:3e6ff5cb9a72 · see in the full table