Molecular Biology of the Cell¶
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2002). Molecular Biology of the Cell.
Cited by¶
8 citations across 8 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Configuration Drift
- In biology, somatic mutations and epigenetic changes cause a cell lineage to diverge from the genome of record while immune recognition continues to assume the original.
This sourceSomatic mutation and epigenetic change cause a cell lineage to diverge from the germline genome of record, with immune surveillance keyed to the original.
- In biology, somatic mutations and epigenetic changes cause a cell lineage to diverge from the genome of record while immune recognition continues to assume the original.
- Counterfactual Subtraction
- Genetics and molecular biology: knockout-versus-wild-type contrast for gene-function attribution; perturbation-versus-baseline transcriptomics.
This sourceEstablishes gene-function inference by contrasting knockout/loss-of-function phenotype against the wild-type baseline — the perturbation-versus-baseline subtraction.
- Genetics and molecular biology: knockout-versus-wild-type contrast for gene-function attribution; perturbation-versus-baseline transcriptomics.
- Information Hiding
- In biology it is the cell membrane as a controlled interface around concealed internal biochemistry, the blood-brain barrier, and hormones as the public contract over hidden organ-level state.
This sourceThe cell membrane as a controlled interface concealing internal biochemistry, exposing receptors as the only permitted crossings, with hormones serving as the public signal over hidden organ-level state.
- In biology it is the cell membrane as a controlled interface around concealed internal biochemistry, the blood-brain barrier, and hormones as the public contract over hidden organ-level state.
- Markov Blanket
- In cell biology, the membrane plus its receptor and transporter inventory is a literal blanket — all matter and signal exchange passes through it, and conditional on membrane state, internal chemistry is independent of external.
This sourceEstablishes the plasma membrane plus its transport proteins and receptors as a selective barrier mediating all matter and signal exchange, so internal chemistry is conditionally independent of the external given membrane state.
- In cell biology, the membrane plus its receptor and transporter inventory is a literal blanket — all matter and signal exchange passes through it, and conditional on membrane state, internal chemistry is independent of external.
- Mixed Layer
- Organizations — front-line and customer-facing staff form a contact zone stirred by high turnover and lateral communication; they buffer the specialized interior (engineering, finance, legal) from direct contact, across a sharp role discontinuity, and the depth to which customer contact penetrates is a managerial variable. Supply chains — a customer-facing inventory buffer is churned by demand, smoothing arrival-rate variance for upstream operations; the boundary between buffer and warehouse is a sharp discontinuity in turn-rate. Computing systems — a hot-data cache is churned by request traffic, locally uniform in access cost, bounded below by a sharp jump to colder storage that it buffers from raw query patterns. Ecology — a forest canopy is stirred by wind and light, locally uniform in microclimate, sharply separated from the still understorey, and mediates all forest-atmosphere exchange. Biology — epithelial and mucous surfaces are continually shed and replaced, buffer underlying tissue from environmental contact, and are bounded below by a sharp basement membrane.
This sourceEpithelial and mucosal surfaces continually shed and renewed, buffering underlying tissue and bounded by a basement membrane.
- Organizations — front-line and customer-facing staff form a contact zone stirred by high turnover and lateral communication; they buffer the specialized interior (engineering, finance, legal) from direct contact, across a sharp role discontinuity, and the depth to which customer contact penetrates is a managerial variable. Supply chains — a customer-facing inventory buffer is churned by demand, smoothing arrival-rate variance for upstream operations; the boundary between buffer and warehouse is a sharp discontinuity in turn-rate. Computing systems — a hot-data cache is churned by request traffic, locally uniform in access cost, bounded below by a sharp jump to colder storage that it buffers from raw query patterns. Ecology — a forest canopy is stirred by wind and light, locally uniform in microclimate, sharply separated from the still understorey, and mediates all forest-atmosphere exchange. Biology — epithelial and mucous surfaces are continually shed and replaced, buffer underlying tissue from environmental contact, and are bounded below by a sharp basement membrane.
- Motif
- Molecular biology: sequence motifs (the TATA box, CpG islands; zinc-finger and leucine-zipper protein-domain motifs) — short distinctive sequences whose recurrence across a genome is the substrate of regulatory and functional inference.
This sourceShort distinctive sequence and structural motifs (TATA box, CpG islands, zinc-finger and leucine-zipper protein domains) whose recurrence is the substrate of regulatory and functional inference.
- Molecular biology: sequence motifs (the TATA box, CpG islands; zinc-finger and leucine-zipper protein-domain motifs) — short distinctive sequences whose recurrence across a genome is the substrate of regulatory and functional inference.
- Principle of Least Privilege
- The identical recipe appears in cell biology: digestive enzymes that would dissolve the cell's own structures are confined inside the lysosome's membrane (the authority bound), so the blast radius of those enzymes is the lysosome's interior.
This sourceDescribes lysosomal membrane compartmentalization confining hydrolytic enzymes, whose release on membrane breach destroys the cell.
- The identical recipe appears in cell biology: digestive enzymes that would dissolve the cell's own structures are confined inside the lysosome's membrane (the authority bound), so the blast radius of those enzymes is the lysosome's interior.
- Publish Subscribe
- In cell biology paracrine and endocrine signalling is publish-subscribe directly: a cell releases a hormone into the extracellular fluid, and any cell expressing the matching receptor responds — the bloodstream is the broker, the receptor is the subscription, identity is anonymous on both sides.
This sourceDescribes endocrine and paracrine signalling (hormones broadcast into the bloodstream, read only by cells with the matching receptor) and transcription-factor binding to genes with the matching site — direct biological instances of topic-routed anonymous signalling.
- In cell biology paracrine and endocrine signalling is publish-subscribe directly: a cell releases a hormone into the extracellular fluid, and any cell expressing the matching receptor responds — the bloodstream is the broker, the receptor is the subscription, identity is anonymous on both sides.
Verification¶
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Links previously used in the corpus¶
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