Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

Brangwynne, C. P., Eckmann, C. R., Courson, D. S., Rybarska, A., Hoege, C., Gharakhani, J., Jülicher, F., et al. (2009). Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation. Science, 324(5935), 1729-1732.

Type

Journal article

Intellectual base

Primary research

Year

2009

Volume

324

Issue

5935

Pages

1729-1732

DOI

10.1126/science.1172046

DOI registrant

American Association for the Advancement of Science

Link

https://doi.org/10.1126/science.1172046

Cited from

chemistry_materials

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Phase Separation
  • The discovery that membraneless organelles form by liquid-liquid phase separation was a wholesale import of the polymer-physics framework into cellular biochemistry, replacing the prior stoichiometric-complex model.

    This sourceThe foundational demonstration that membraneless organelles behave as liquid phases (a classic phase transition), importing polymer-physics LLPS into cell biology.

    Supported in partVerified against the publisher's abstract

    The abstract shows P granules localize by controlled dissolution/condensation — an LLPS demonstration — but says nothing of polymer-physics import, stoichiometric-complex replacement, or urban segregation.

    “Now Brangwynne et al. (p. 1729 , published online 21 May; see the Perspective by Le Goff and Lecuit ) provide evidence that localization occurs by a quite different mechanism, controlled dissolution and condensation of granule components.”

    Read by an automated reader; not a human review. How support was checked

Verification

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Registry ID ref:43dad32520ef · see in the full table