External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients.¶
Wong, A., Otles, E., Donnelly, J. P., Krumm, A., McCullough, J., DeTroyer-Cooley, O., Pestrue, J., et al. (2021). External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients. JAMA Internal Medicine, 181(8), 1065-1070.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Shortcut Learning
- In clinical prediction it is the sepsis-risk model that fires whenever a clinician has already ordered a sepsis workup, predicting the chart rather than the patient.
This sourceExternal validation of the Epic Sepsis Model; discrimination assessed relative to clinician recognition (antibiotic/culture/lactate orders), highlighting how such early-warning models can key on documentation/workup artifacts that track clinician suspicion rather than the patient's underlying state.
- In clinical prediction it is the sepsis-risk model that fires whenever a clinician has already ordered a sepsis workup, predicting the chart rather than the patient.
- Training Serving Skew
- The structurally identical analysis applies to an infantry company meeting an unfamiliar opposing doctrine and degraded comms, and to a sepsis protocol piloted with research nurses and high-fidelity monitoring that reverses when rolled out to community hospitals without either.
This sourceThe Epic Sepsis Model, deployed at hundreds of hospitals, showed poor discrimination and calibration on external validation — degraded performance when carried from development to ordinary deployment sites.
- The structurally identical analysis applies to an infantry company meeting an unfamiliar opposing doctrine and degraded comms, and to a sepsis protocol piloted with research nurses and high-fidelity monitoring that reverses when rolled out to community hospitals without either.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:43e18d47905e · see in the full table