A novel process-based model of microbial growth¶
Mazzoleni, S., Landi, C., Cartenì, F., de Alteriis, E., Giannino, F., Paciello, L., & Parascandola, P. (2015). A novel process-based model of microbial growth: self-inhibition in Saccharomyces cerevisiae aerobic fed-batch cultures. Microbial Cell Factories, 14.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Bloom And Bust Cycle
- Imperial overstretch and fermentation: rapid expansion then contraction leaving disrupted zones and displaced populations; a sugar pulse driving yeast growth whose alcohol byproducts collapse the population and sterilise the substrate.
This sourceModels aerobic S. cerevisiae growth on glucose with inhibition from the accumulation of both ethanol and other self-produced toxic compounds, showing that a negative feedback by self-produced inhibitory compounds caps the maximum cell density and drives the growth decline in prolonged cultures -- the fermentation self-poisoning aftermath. NB: the paper attributes the prolonged-decline phase specifically to self-produced inhibitory compounds OTHER than ethanol, so it supports the general self-inhibition mechanism but qualifies the prose's attribution of the collapse to 'alcohol byproducts' -- see prose flag on marker 555.
- Imperial overstretch and fermentation: rapid expansion then contraction leaving disrupted zones and displaced populations; a sugar pulse driving yeast growth whose alcohol byproducts collapse the population and sterilise the substrate.
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