Theory of Protein Folding¶
Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997). Theory of Protein Folding: The Energy Landscape Perspective. Annual Review of Physical Chemistry, 48, 545-600.
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Primes¶
- Optimization Landscape
- … recurs in chemistry and materials (potential energy surfaces where conformations occupy basins and transition states are saddle points), in protein folding (the funnel-shaped energy landscape that channels conformations toward the native state, with misfolding diseases corresponding to alternative basins
This sourceFunnel-shaped folding landscape, with misfolding as alternative off-funnel basins.
- … recurs in chemistry and materials (potential energy surfaces where conformations occupy basins and transition states are saddle points), in protein folding (the funnel-shaped energy landscape that channels conformations toward the native state, with misfolding diseases corresponding to alternative basins
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