Theory of Protein Folding¶
Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997). Theory of Protein Folding: The Energy Landscape Perspective. Annual Review of Physical Chemistry, 48, 545-600.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Optimization Landscape
- … recurs in chemistry and materials (potential energy surfaces where conformations occupy basins and transition states are saddle points), in protein folding (the funnel-shaped energy landscape that channels conformations toward the native state, with misfolding diseases corresponding to alternative basins
This sourceFunnel-shaped folding landscape, with misfolding as alternative off-funnel basins.
Supported in partVerified against the publisher's abstract
The abstract states a rugged, funnel-like folding landscape biased toward the native structure, but says nothing about misfolding diseases as alternative basins, nor about chemistry or materials surfaces.
“It suggests that the most realistic model of a protein is a minimally frustrated heteropolymer with a rugged funnel-like landscape biased toward the native structure.”
- … recurs in chemistry and materials (potential energy surfaces where conformations occupy basins and transition states are saddle points), in protein folding (the funnel-shaped energy landscape that channels conformations toward the native state, with misfolding diseases corresponding to alternative basins
Verification¶
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Registry ID ref:470f4c439a8e · see in the full table