Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine¶
Ritz. (1987). Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine. Science.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Neurotransmission
- This is the inference that organizes the canonical reading of a drug like cocaine: it blocks the dopamine transporter, prolonging dopamine's residence in the cleft and amplifying the postsynaptic effect
This sourceThe study relating cocaine-like drugs' self-administration potency to their inhibition of dopamine-transporter binding, proposing the transporter as the cocaine receptor relevant to abuse.
Supported in partVerified against the publisher's abstract
“the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum”
- This is the inference that organizes the canonical reading of a drug like cocaine: it blocks the dopamine transporter, prolonging dopamine's residence in the cleft and amplifying the postsynaptic effect
Verification¶
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Registry ID ref:4a4d9d640b3f · see in the full table