Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease¶
Cohen, J. C. (2006). Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Instrumental variable
- To test whether lifelong lower LDL cholesterol actually reduces coronary heart disease — as opposed to merely correlating with it through diet, exercise, and other confounders — researchers use genetic variants (e.g., in or near the PCSK9 gene) that are associated with lower LDL
This sourcePCSK9 sequence variants that lower LDL used to test the effect of lifelong lower LDL on coronary heart disease, finding large reductions in CHD risk.
SupportedVerified against the source
- To test whether lifelong lower LDL cholesterol actually reduces coronary heart disease — as opposed to merely correlating with it through diet, exercise, and other confounders — researchers use genetic variants (e.g., in or near the PCSK9 gene) that are associated with lower LDL
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