Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption¶
Nehlig, A. (2018). Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacological Reviews, 5-5.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Metabolic Inactivation
- The inactivation rate sets caffeine's half-life at roughly 4–5 hours in a healthy non-smoking adult — which is why an afternoon coffee can still impair sleep
This sourceHow smoking roughly doubles caffeine metabolism through CYP1A2 induction while pregnancy and oral contraceptives substantially lengthen caffeine's half-life.
Supported in partVerified against the source
- The inactivation rate sets caffeine's half-life at roughly 4–5 hours in a healthy non-smoking adult — which is why an afternoon coffee can still impair sleep
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