Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition.¶
Pouille, F., & Scanziani, M. (2001). Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition. Science, 293(5532), 1159-1163.
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Primes¶
- Feedforward Inhibition
- In neuroscience, the origin, thalamocortical and hippocampal circuits use feedforward inhibition to enforce narrow temporal integration windows: an afferent excites a target cell directly and drives an interneuron that inhibits the same cell a moment later, so inputs inside the window summate and later inputs are clipped, producing precise timing and sparse coding.
This sourceDemonstrates disynaptic feedforward inhibition imposing a narrow (<2 ms) temporal integration window on hippocampal pyramidal cells via the short delay of disynaptic inhibition following monosynaptic excitation — the canonical feedforward-inhibition microcircuit.
- In neuroscience, the origin, thalamocortical and hippocampal circuits use feedforward inhibition to enforce narrow temporal integration windows: an afferent excites a target cell directly and drives an interneuron that inhibits the same cell a moment later, so inputs inside the window summate and later inputs are clipped, producing precise timing and sparse coding.
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