The Genetic Signature of Conditional Expression¶
Van Dyken, J. D., & Wade, M. J. (2010). The Genetic Signature of Conditional Expression. Genetics.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Selection-Visibility Gate
- The access stage sits strictly upstream of the selector and is causally independent of it; the selector need not know the stage exists, and typically does not. Expression is graded rather than binary — penetrance, sampling rate, reporting probability and coverage all set an aperture somewhere between zero and one. Effective pressure on a trait is its true consequence discounted by its probability of expression, so a large effect that rarely surfaces behaves exactly like a small effect.
This sourceShows that the strength of selection on a conditionally expressed gene is discounted by the fraction of individuals expressing it, so a rarely expressed gene behaves like a weakly selected one and accumulates deleterious mutations accordingly.
Supported in partVerified against the publisher's abstract
The abstract supports the discounting principle: selection strength is weakened by the fraction φ expressing the gene, and rarer expression recruits more sites into neutrality.
“Conditionally expressed genes have the property that every individual in a population carries and transmits the gene, but only a fraction, ϕ, expresses the gene and exposes it to natural selection. We show that a consequence of this pattern of inheritance and expression is a weakening of the strength of natural selection, allowing deleterious mutations to accumulate within and between species and inhibiting the …”
- The access stage sits strictly upstream of the selector and is causally independent of it; the selector need not know the stage exists, and typically does not. Expression is graded rather than binary — penetrance, sampling rate, reporting probability and coverage all set an aperture somewhere between zero and one. Effective pressure on a trait is its true consequence discounted by its probability of expression, so a large effect that rarely surfaces behaves exactly like a small effect.
Verification¶
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Registry ID ref:55bb3570b313 · see in the full table