The Genetic Signature of Conditional Expression¶
Van Dyken, J. D., & Wade, M. J. (2010). The Genetic Signature of Conditional Expression. Genetics.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Selection-Visibility Gate
- The access stage sits strictly upstream of the selector and is causally independent of it; the selector need not know the stage exists, and typically does not. Expression is graded rather than binary — penetrance, sampling rate, reporting probability and coverage all set an aperture somewhere between zero and one. Effective pressure on a trait is its true consequence discounted by its probability of expression, so a large effect that rarely surfaces behaves exactly like a small effect.
This sourceShows that the strength of selection on a conditionally expressed gene is discounted by the fraction of individuals expressing it, so a rarely expressed gene behaves like a weakly selected one and accumulates deleterious mutations accordingly.
- The access stage sits strictly upstream of the selector and is causally independent of it; the selector need not know the stage exists, and typically does not. Expression is graded rather than binary — penetrance, sampling rate, reporting probability and coverage all set an aperture somewhere between zero and one. Effective pressure on a trait is its true consequence discounted by its probability of expression, so a large effect that rarely surfaces behaves exactly like a small effect.
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Registry ID ref:55bb3570b313 · see in the full table