Clinical Pharmacology of Buprenorphine¶
Walsh, S. L., Preston, K. L., Stitzer, M. L., Cone, E. J., & Bigelow, G. E. (1994). Clinical Pharmacology of Buprenorphine: Ceiling Effects at High Doses. Clinical Pharmacology and Therapeutics, 55(5), 569-580.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Intrinsic Ceiling vs Input
- For maintenance and overdose-resistance, the safety-from-ceiling property dominates: buprenorphine's low respiratory-depression ceiling means additional dose cannot push respiratory suppression past a bounded maximum, which is the structural basis of its safety profile.
This sourceDemonstrates buprenorphine's ceiling effect on respiratory depression — additional dose cannot push the response past a bounded maximum — the structural basis of its safety profile.
Supported in partVerified against the publisher's abstract
The abstract reports a plateau in buprenorphine's dose-response for respiratory depression in nondependent male volunteers, which backs the ceiling principle but not the maintenance or overdose-resistance frame.
“A plateau was observed for the dose effects of buprenorphine on subjective measures and respiratory depression.”
- For maintenance and overdose-resistance, the safety-from-ceiling property dominates: buprenorphine's low respiratory-depression ceiling means additional dose cannot push respiratory suppression past a bounded maximum, which is the structural basis of its safety profile.
Verification¶
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Registry ID ref:567d8224c0e7 · see in the full table