Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex.¶
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002). Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex. Science, 1248-1251.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Critical Period
- The intervention design the prime says follows from a known closing mechanism is precisely what the field has demonstrated: because the closing is caused by mature inhibition and perineuronal nets, the window can be experimentally reopened in adult animals by chemically degrading the nets or dialing down inhibition, restoring juvenile-like plasticity — the prime's window-extension move realized molecularly.
This sourceShows chondroitinase-ABC degradation of perineuronal nets reopens juvenile-like ocular-dominance plasticity in adult rat visual cortex — the window-extension move realized molecularly.
Supported in partVerified against the publisher's abstract
The abstract shows chondroitinase-ABC degradation of perineuronal nets (CSPGs) in adult rats restores ocular-dominance plasticity; it says nothing about dialing down inhibition.
“The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.”
- The intervention design the prime says follows from a known closing mechanism is precisely what the field has demonstrated: because the closing is caused by mature inhibition and perineuronal nets, the window can be experimentally reopened in adult animals by chemically degrading the nets or dialing down inhibition, restoring juvenile-like plasticity — the prime's window-extension move realized molecularly.
Verification¶
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