Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.¶
Alberti, S., Gladfelter, A., & Mittag, T. (2019). Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates. Cell, 176(3), 419-434.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Spinodal Decomposition
- The intervention menu transfers intact — to dissolve pathological condensates (implicated in ALS and neurodegeneration, where granules harden into irreversible aggregates, the morphological lock-in failure mode) one changes the operating point (lower concentration) or the landscape (phosphorylation that alters the protein's interaction free energy), not the noise.
This sourceReviews condensate formation and the maturation/hardening of liquid droplets into irreversible aggregates (implicated in ALS/neurodegeneration), and how changing concentration or post-translational modification reshapes the phase landscape.
Supported in partVerified against the work's full text
Supports condensates in ALS/neurodegeneration maturing from liquid to solid or aggregated states; does not discuss lowering concentration or phosphorylation as ways to dissolve them.
“Stress granule proteins form liquid condensates that can mature and solidify, i.e. they can undergo liquid-to-solid transitions, or can nucleate aggregation”
- The intervention menu transfers intact — to dissolve pathological condensates (implicated in ALS and neurodegeneration, where granules harden into irreversible aggregates, the morphological lock-in failure mode) one changes the operating point (lower concentration) or the landscape (phosphorylation that alters the protein's interaction free energy), not the noise.
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