Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.¶
Alberti, S., Gladfelter, A., & Mittag, T. (2019). Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates. Cell, 176(3), 419-434.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Spinodal Decomposition
- The intervention menu transfers intact — to dissolve pathological condensates (implicated in ALS and neurodegeneration, where granules harden into irreversible aggregates, the morphological lock-in failure mode) one changes the operating point (lower concentration) or the landscape (phosphorylation that alters the protein's interaction free energy), not the noise.
This sourceReviews condensate formation and the maturation/hardening of liquid droplets into irreversible aggregates (implicated in ALS/neurodegeneration), and how changing concentration or post-translational modification reshapes the phase landscape.
- The intervention menu transfers intact — to dissolve pathological condensates (implicated in ALS and neurodegeneration, where granules harden into irreversible aggregates, the morphological lock-in failure mode) one changes the operating point (lower concentration) or the landscape (phosphorylation that alters the protein's interaction free energy), not the noise.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:589cd022ae0e · see in the full table