Guidelines for Human Gene Nomenclature

Bruford, E. A., Braschi, B., Denny, P., Jones, T. E. M., Seal, R. L., & Tweedie, S. (2020). Guidelines for Human Gene Nomenclature. Nature Genetics, 52, 754-758.

Type

Journal article

Intellectual base

Primary research

Year

2020

DOI

10.1038/s41588-020-0669-3

Link

https://doi.org/10.1038/s41588-020-0669-3

Cited from

biology_ecology, linguistics_semiotics

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Naming Convention
  • In biological nomenclature, a gene-symbol convention does the same structural job for a different community: the generator mints symbols from defined rules, the grammar constrains form (allowed characters, length, casing), the uniqueness discipline prevents two genes from sharing a symbol and resolves clashes through the authority, and the community commitment is the naming committee plus the field's agreement to use approved symbols.

    This sourceDescribes the HUGO Gene Nomenclature Committee's rules for minting unique human gene symbols, the disambiguation discipline, validator services, and deprecation-with-replacement amendment — a gene-symbol naming convention with an enforcing authority.

• Alias-to-Authority Mapping
  • In bioinformatics, registries maintain a canonical symbol while routing legacy aliases to it, without which cross-study meta-analyses would double-count.

    This sourceA canonical gene symbol is maintained while legacy aliases and superseded symbols resolve to it, preventing double-counting in meta-analysis.

Verification

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