Guidelines for Human Gene Nomenclature¶
Bruford, E. A., Braschi, B., Denny, P., Jones, T. E. M., Seal, R. L., & Tweedie, S. (2020). Guidelines for Human Gene Nomenclature. Nature Genetics, 52, 754-758.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Naming Convention
- In biological nomenclature, a gene-symbol convention does the same structural job for a different community: the generator mints symbols from defined rules, the Grammar constrains form (allowed characters, length, casing), the uniqueness discipline prevents two genes from sharing a symbol and resolves clashes through the authority, and the community commitment is the naming committee plus the field's agreement to use approved symbols.
This sourceDescribes the HUGO Gene Nomenclature Committee's rules for minting unique human gene symbols, the disambiguation discipline, validator services, and deprecation-with-replacement amendment — a gene-symbol naming convention with an enforcing authority.
SupportedVerified against the work's full text
The HGNC guidelines set out the committee's authority, the form rules for symbols, one unique symbol per gene, negotiated alternatives when a request can't be approved, and the push for approved use.
“Each gene is assigned a unique symbol, HGNC ID and descriptive name. Symbols contain only uppercase Latin letters and Arabic numerals.”
- In biological nomenclature, a gene-symbol convention does the same structural job for a different community: the generator mints symbols from defined rules, the Grammar constrains form (allowed characters, length, casing), the uniqueness discipline prevents two genes from sharing a symbol and resolves clashes through the authority, and the community commitment is the naming committee plus the field's agreement to use approved symbols.
- Alias-to-Authority Mapping
- In bioinformatics, registries maintain a canonical symbol while routing legacy aliases to it, without which cross-study meta-analyses would double-count.
This sourceA canonical gene symbol is maintained while legacy aliases and superseded symbols resolve to it, preventing double-counting in meta-analysis.
Supported in partVerified against the work's full text
HGNC guidance supports stable gene identification so data can be tracked through symbol changes, but not alias routing or double-counting in meta-analysis.
“This ensures effective and reliable tracking of data regardless of any nomenclature changes.”
- In bioinformatics, registries maintain a canonical symbol while routing legacy aliases to it, without which cross-study meta-analyses would double-count.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 2 of 2 citations: 1 supported, 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:59792871bd9b · see in the full table