Active Learning-Assisted Directed Evolution.¶
Yang, J., Lal, R. G., Bowden, J. C., Astudillo, R., Hameedi, M. A., Kaur, S., Hill, M., et al. (2025). Active Learning-Assisted Directed Evolution. Nature Communications, 16.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Fuzzing
- The further claim that software-side advances such as feedback-guided generation and triggering-input minimization were imported into directed-evolution lab practice does not survive checking: the feedback loop directed evolution actually acquired is machine-learning-derived, and the work describing it makes no reference to fuzzing.
This sourceCited as adverse to the claim this sentence used to make: the feedback loop directed evolution actually adopted is machine-learning-derived — "A supervised ML model with uncertainty quantification is trained to learn a mapping from sequence to fitness" — and the paper, from Frances Arnold's own group, makes no reference to software fuzzing. No located source documents a transfer of fuzzing technique into wet-lab directed-evolution practice.
Supported in partVerified against the publisher's abstract
The abstract shows an ML-assisted directed-evolution workflow, backing the ML-derived feedback-loop half of the claim but not the assertion about fuzzing.
“Here, we present Active Learning-assisted Directed Evolution (ALDE), an iterative machine learning-assisted DE workflow that leverages uncertainty quantification to explore the search space of proteins more efficiently than current DE methods.”
- The further claim that software-side advances such as feedback-guided generation and triggering-input minimization were imported into directed-evolution lab practice does not survive checking: the feedback loop directed evolution actually acquired is machine-learning-derived, and the work describing it makes no reference to fuzzing.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:5e47fce8d0aa · see in the full table