The Clonal Selection Theory of Acquired Immunity¶
Burnet, F. M. (1959). The Clonal Selection Theory of Acquired Immunity. Vanderbilt University Press.
Cited by¶
6 citations across 6 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Disjointness
- In immunology, self-versus-non-self discrimination is a disjointness judgment over molecular markers, and autoimmunity is its failure.
This sourceFoundational immunological account of self/non-self discrimination as a disjointness judgment over molecular markers, with autoimmunity as the breakdown of that separation.
- In immunology, self-versus-non-self discrimination is a disjointness judgment over molecular markers, and autoimmunity is its failure.
- Interpretation
- … a thermostat with a learned setpoint, or a seismic monitoring system reading subsurface motion into earthquake-or-not classifications — readings whose framework, in the biological case, was first articulated as a selection-trained discriminator by Burnet (1959) in the clonal-selection theory of antibody response.
This sourceFoundational formulation of clonal selection: antigen exposure selects from a pre-existing diverse lymphocyte repertoire, and selected clones persist as immune memory. Establishes adaptive immunity as a substrate-furthest case of the learning skeleton — modifiable repertoire, experiential input, selection-and-mutation update, lifelong durability — entirely without cognition or instruction.
- … a thermostat with a learned setpoint, or a seismic monitoring system reading subsurface motion into earthquake-or-not classifications — readings whose framework, in the biological case, was first articulated as a selection-trained discriminator by Burnet (1959) in the clonal-selection theory of antibody response.
- Learning
- No cognition, no language, no consciousness — and yet every role in the structural pattern is cleanly present, as Burnet (1959) established in formulating the clonal selection theory that underwrites adaptive immune memory.
This sourceFoundational formulation of clonal selection: antigen exposure selects from a pre-existing diverse lymphocyte repertoire, and selected clones persist as immune memory. Establishes adaptive immunity as a substrate-furthest case of the learning skeleton — modifiable repertoire, experiential input, selection-and-mutation update, lifelong durability — entirely without cognition or instruction.
- No cognition, no language, no consciousness — and yet every role in the structural pattern is cleanly present, as Burnet (1959) established in formulating the clonal selection theory that underwrites adaptive immune memory.
- Natural Selection
- In immunology the same engine runs within a single organism on a timescale of days: clonal selection and affinity maturation are natural selection of B-cell lineages, in which antibody-producing cells vary (through somatic hypermutation), are differentially reproduced according to how tightly they bind the antigen (the selection pressure), and the high-affinity survivors are retained and expanded — a textbook instance of the population, the discriminating pressure, and the heritable retention, distinguished only by the substrate and the speed.
This sourceEstablishes clonal selection — antibody-producing cell lineages varying, differentially reproduced by antigen binding, and clonally expanded — as natural selection running within one organism; the basis of affinity maturation.
- In immunology the same engine runs within a single organism on a timescale of days: clonal selection and affinity maturation are natural selection of B-cell lineages, in which antibody-producing cells vary (through somatic hypermutation), are differentially reproduced according to how tightly they bind the antigen (the selection pressure), and the high-affinity survivors are retained and expanded — a textbook instance of the population, the discriminating pressure, and the heritable retention, distinguished only by the substrate and the speed.
- Pull Flow
- Immunology — antigen-pulled clonal expansion versus constitutive innate-immune surveillance.
This sourceFoundational statement that antigen encounter selectively pulls clonal expansion of matching lymphocytes — antigen-driven (pull) versus constitutive immune activity.
- Immunology — antigen-pulled clonal expansion versus constitutive innate-immune surveillance.
- Sparse Coding
Verification¶
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