Something from “Nothing” − Eight Weak Estrogenic Chemicals Combined at Concentrations below NOECs Produce Significant Mixture Effects¶
Silva, E., Rajapakse, N., & Kortenkamp, A. (2002). Something from “Nothing” − Eight Weak Estrogenic Chemicals Combined at Concentrations below NOECs Produce Significant Mixture Effects. Environmental Science & Technology.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- NOAEL (No Observed Adverse Effect Level)
- Components each held below their own no-observed-effect concentration can still combine into a substantial joint effect, so single-substance no-effect anchors poorly predict the toxicity of co-exposures
This sourceShows eight weak estrogenic chemicals, each held below its own no-observed-effect concentration, producing a significant combined effect in a recombinant yeast estrogen screen — so single-substance no-effect anchors do not predict the mixture.
SupportedVerified against the source
- Components each held below their own no-observed-effect concentration can still combine into a substantial joint effect, so single-substance no-effect anchors poorly predict the toxicity of co-exposures
Verification¶
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Registry ID ref:6c8d6e7d3d19 · see in the full table