Fear Memories Require Protein Synthesis in the Amygdala for Reconsolidation After Retrieval.

Nader, K., Schafe, G. E., & Le Doux, J. E. (2000). Fear Memories Require Protein Synthesis in the Amygdala for Reconsolidation After Retrieval. Nature, 406(6797), 722-726.

Type

Journal article

Intellectual base

Review or monograph

Year

2000

DOI

10.1038/35021052

Link

https://doi.org/10.1038/35021052

Cited from

biology_ecology, neuroscience

Cited by

3 citations across 3 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Memory Consolidation
  • And reconsolidation-window interventions move directly from laboratory research to clinical treatment.

    This sourceShows retrieved memories re-enter a labile state and must reconsolidate, opening a window for editing the consolidated trace.

• Reconsolidation
  • In neuroscience, a reactivated fear memory can be eliminated by blocking protein synthesis during the post-retrieval window, and the principle generalizes to therapeutic memory-update treatment.

    This sourceDemonstrates that a reactivated fear memory returns to a labile state and can be eliminated by blocking protein synthesis in the amygdala during the post-retrieval window.

Mechanisms

• Corrective Experience Pairing
  • This is the associative-learning heart of the archetype: the corrective difference is felt, then re-stored.

    This sourceShows in conditioned rats that retrieval makes a consolidated fear memory labile and dependent on de novo protein synthesis for reconsolidation; it does not test incorporation of a corrective experience.

Verification

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