Fear Memories Require Protein Synthesis in the Amygdala for Reconsolidation After Retrieval.¶
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000). Fear Memories Require Protein Synthesis in the Amygdala for Reconsolidation After Retrieval. Nature, 406(6797), 722-726.
Cited by¶
5 citations across 5 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Memory Consolidation
- And reconsolidation-window interventions move directly from laboratory research to clinical treatment.
This sourceShows retrieved memories re-enter a labile state and must reconsolidate, opening a window for editing the consolidated trace.
Supported in partVerified against the publisher's abstract
Abstract shows a manipulable reconsolidation window in rats; it says nothing about clinical treatment or translation to patients.
“consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests”
- And reconsolidation-window interventions move directly from laboratory research to clinical treatment.
- Reconsolidation
- In neuroscience, a reactivated fear memory can be eliminated by blocking protein synthesis during the post-retrieval window, and the principle generalizes to therapeutic memory-update treatment.
This sourceDemonstrates that a reactivated fear memory returns to a labile state and can be eliminated by blocking protein synthesis in the amygdala during the post-retrieval window.
Supported in partVerified against the publisher's abstract
The abstract states that reactivated fear memories return to a labile state in which anisomycin shortly after retrieval produces amnesia, but says nothing about generalization to therapeutic memory-update treatment.
“Here we show that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning.”
- In neuroscience, a reactivated fear memory can be eliminated by blocking protein synthesis during the post-retrieval window, and the principle generalizes to therapeutic memory-update treatment.
Mechanisms¶
- Checklist Micro-Rehearsal
- The classic misuse is letting the run-through drift into quietly modifying the procedure on the fly — retrieving a memory can briefly make it labile and open to alteration,
This sourceRetrieved consolidated fear memories can temporarily return to a labile state before reconsolidation.
- The classic misuse is letting the run-through drift into quietly modifying the procedure on the fly — retrieving a memory can briefly make it labile and open to alteration,
- Corrective Experience Pairing
- This is the associative-learning heart of the archetype: the corrective difference is felt, then re-stored.
This sourceShows in conditioned rats that retrieval makes a consolidated fear memory labile and dependent on de novo protein synthesis for reconsolidation; it does not test incorporation of a corrective experience.
- This is the associative-learning heart of the archetype: the corrective difference is felt, then re-stored.
- Reconsolidation or Reopening Protocol
Verification¶
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Does it back the claim? Read against the text for 2 of 5 citations: 2 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
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