The therapeutic index¶
Muller, P. Y., & Milovanovic, A. (2008). The therapeutic index: A new perspective. Pharmacology & Therapeutics, 119(2), 173-183.
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Primes¶
- Therapeutic Window
- The separation of the two curves is measured quantitatively as a therapeutic index (the ratio LD50/ED50, TD50/ED50, or similar), therapeutic margin (the absolute difference or log-ratio), or simply the ratio of the upper to lower bound, as Muller and Milovanovic (2008) formalize in their treatment of the therapeutic index in pharmacology and therapeutics.
This sourceFormal review of the therapeutic index as the quantitative ratio LD50/ED50 (or analogous TD50/ED50), distinguishing index from window width and surveying its use across drug classes.
- The separation of the two curves is measured quantitatively as a therapeutic index (the ratio LD50/ED50, TD50/ED50, or similar), therapeutic margin (the absolute difference or log-ratio), or simply the ratio of the upper to lower bound, as Muller and Milovanovic (2008) formalize in their treatment of the therapeutic index in pharmacology and therapeutics.
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