Fomepizole for Ethylene Glycol and Methanol Poisoning¶
Brent. (2009). Fomepizole for Ethylene Glycol and Methanol Poisoning.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Enzyme Inhibition
- raise plasma exposure of co-administered substrates; the interaction landscape is mapped through inhibitor/substrate/contraindication tables and quantified via Ki-fed PBPK models that predict the AUC rise. Therapeutic enzyme inhibition by design — whole drug classes are precise inhibition of a named enzyme: ACE inhibitors on the renin-angiotensin pathway, statins on HMG-CoA reductase, PDE5 inhibitors on cGMP degradation, HIV protease inhibitors on viral maturation. Toxicology — organophosphate pesticides irreversibly (mechanism-based) inactivate acetylcholinesterase, heavy metals inhibit multiple metabolic enzymes, and competitive-inhibitor antidotes (fomepizole for methanol / ethylene-glycol poisoning) are inhibition deployed as treatment.
This sourceClinical case review reporting that fomepizole, a competitive inhibitor of alcohol dehydrogenase, prevents formation of the toxic metabolites of ethylene glycol and methanol.
Supported in partVerified against the source
- raise plasma exposure of co-administered substrates; the interaction landscape is mapped through inhibitor/substrate/contraindication tables and quantified via Ki-fed PBPK models that predict the AUC rise. Therapeutic enzyme inhibition by design — whole drug classes are precise inhibition of a named enzyme: ACE inhibitors on the renin-angiotensin pathway, statins on HMG-CoA reductase, PDE5 inhibitors on cGMP degradation, HIV protease inhibitors on viral maturation. Toxicology — organophosphate pesticides irreversibly (mechanism-based) inactivate acetylcholinesterase, heavy metals inhibit multiple metabolic enzymes, and competitive-inhibitor antidotes (fomepizole for methanol / ethylene-glycol poisoning) are inhibition deployed as treatment.
Verification¶
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Registry ID ref:6d8b01b33f6e · see in the full table