Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors¶
Burris, K. D. (2002). Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors. The Journal of Pharmacology and Experimental Therapeutics.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Partial Agonist
- aripiprazole's partial agonism at dopamine D2 receptors stabilizes dopaminergic tone — acting as a net agonist in hypo-dopaminergic states and a net antagonist in hyper-dopaminergic ones — supporting its use across both positive and negative symptoms of psychosis
This sourceAripiprazole's partial agonism at human dopamine D2 receptors, reading as agonist or antagonist according to dopaminergic tone.
Supported in partVerified against a saved copy of the source
“Aripiprazole displays properties of an agonist and antagonist in animal models of dopaminergic hypoactivity and hyperactivity, respectively.”
- aripiprazole's partial agonism at dopamine D2 receptors stabilizes dopaminergic tone — acting as a net agonist in hypo-dopaminergic states and a net antagonist in hyper-dopaminergic ones — supporting its use across both positive and negative symptoms of psychosis
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