Developmental pharmacology—Drug disposition, action, and therapy in infants and children¶
Kearns, G. L., Abdel-Rahman, Alander, Blowey, Leeder, & Kauffman, R. E. (2003). Developmental pharmacology—Drug disposition, action, and therapy in infants and children. New England Journal of Medicine, 349(12), 1157-1167.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Therapeutic Window
- Kearns, Abdel-Rahman, Alander, Blowey, Leeder, and Kauffman (2003) document how developmental pharmacology shifts windows substantially across pediatric age strata.
This sourceFoundational developmental-pharmacology review: documents how PK/PD parameters and therapeutic windows shift across pediatric age strata, often substantially, invalidating direct adult-to-pediatric dose extrapolation.
- Kearns, Abdel-Rahman, Alander, Blowey, Leeder, and Kauffman (2003) document how developmental pharmacology shifts windows substantially across pediatric age strata.
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