Fitness Seascapes Are Necessary for Realistic Modeling of the Evolutionary Response to Drug Therapy

King, E. S., & Scott, J. G. (2025). Fitness Seascapes Are Necessary for Realistic Modeling of the Evolutionary Response to Drug Therapy. Science Advances, 11(24).

Type

Journal article

Intellectual base

Primary research

Year

2025

Volume

11

Issue

24

DOI

10.1126/sciadv.adv1268

DOI registrant

American Association for the Advancement of Science

Link

https://doi.org/10.1126/sciadv.adv1268

Cited by

1 citation across 1 artifact.

Domain-specific

• Fitness seascape
  • … under one condition can become neutral or deleterious after the selective surface moves to A cancer-evolution model compares static and time-varying fitness maps under a changing therapy environment to test whether adaptive trajectories require an explicit seascape representation demonstrates that continuity.

Verification

Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.

Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.

Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.

See how references were verified.

Registry ID ref:73317c9dd836 · see in the full table