Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model¶
Cacucci. (2008). Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model. Proceedings of the National Academy of Sciences.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Place Field
- Fields are stable across visits to the same environment in healthy animals but remap when the environment changes substantially; instability of fields under fixed environmental conditions is a sensitive marker of hippocampal dysfunction, reported in Alzheimer's disease mouse models as degraded place-field representations that track the animals' spatial-memory impairment and amyloid plaque burden
This sourceReport that aged Tg2576 mice show degraded place-cell representations of the environment, correlating with spatial-memory impairment and hippocampal amyloid plaque burden, and proposing place-cell recording as a sensitive assay of functional deterioration. Report that aged Tg2576 mice show reduced spatial information content and enlarged place fields relative to littermate controls in a familiar environment. The Tg2576 result that the level of place-cell degradation correlates with the animals' poorer spatial-memory performance and with hippocampal (but not neocortical) amyloid plaque burden.
Supported in partVerified against the source
- Fields are stable across visits to the same environment in healthy animals but remap when the environment changes substantially; instability of fields under fixed environmental conditions is a sensitive marker of hippocampal dysfunction, reported in Alzheimer's disease mouse models as degraded place-field representations that track the animals' spatial-memory impairment and amyloid plaque burden
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Registry ID ref:733b2d596031 · see in the full table