Genomically Recoded Organisms Expand Biological Functions.

Lajoie, M. J., Rovner, A. J., Goodman, D. B., Aerni, H., Haimovich, A. D., Kuznetsov, G., Mercer, J. A., et al. (2013). Genomically Recoded Organisms Expand Biological Functions. Science, 342(6156), 357-360.

Type

Journal article

Intellectual base

Primary research

Year

2013

Volume

342

Issue

6156

Pages

357-360

DOI

10.1126/science.1241459

DOI registrant

American Association for the Advancement of Science

Link

https://doi.org/10.1126/science.1241459

Cited from

mathematics

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Formal System
  • And treating the genetic code as a formal system enabled designed genetic re-coding in synthetic biology.

    This sourceReassigns all UAG codons across the E. coli genome and deletes release factor 1 — treating the genetic code as a formal rule-system whose symbols and inference can be re-engineered, enabling designed recoding.

    Supported in partVerified against the work's full text

    The paper demonstrates designed genome-wide recoding of E. coli (UAG reassignment, RF1 deletion) but never frames the genetic code as a formal system.

    “That is, UAG has been transformed from a nonsense codon (terminates translation) to a sense codon (incorporates amino acid of choice), provided the appropriate translation machinery is present.”

    Read by an automated reader; not a human review. How support was checked

Verification

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