Positive and Negative Selection of T Cells.¶
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003). Positive and Negative Selection of T Cells. Annual Review of Immunology, 139-176.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Pruning
- Evolutionary biology — over-production of offspring or variants followed by selective survival; T-cell repertoire pruning by negative selection in the thymus.
This sourceReviews negative selection in the thymus, which prunes self-reactive T cells from an over-generated repertoire.
Supported in partVerified against the publisher's abstract
The abstract places T-cell positive and negative selection in the thymus and ties negative selection to tolerance of self-antigens, which is the pruning mechanism the bullet's second clause names.
“This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection”
- Evolutionary biology — over-production of offspring or variants followed by selective survival; T-cell repertoire pruning by negative selection in the thymus.
Verification¶
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