Plasma HDL cholesterol and risk of myocardial infarction¶
Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., et al. (2012). Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. The Lancet.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Natural Experiment
- But Mendelian-randomization analyses (Voight and colleagues, 2012) used a genetic variant that raises HDL and found carriers had no lower risk of heart attack — evidence that some HDL-raising mechanisms do not lower risk, so raising HDL cannot be assumed to reduce it.
This sourceVoight and colleagues' Mendelian-randomisation test of the HDL-raising LIPG Asn396Ser variant, whose carriers showed no reduction in myocardial-infarction risk (OR 0.99, 95% CI 0.88-1.11) despite higher HDL - the paper's own conclusion being that some HDL-raising mechanisms do not lower risk and that raising HDL will not uniformly reduce it.
SupportedVerified against the source
- But Mendelian-randomization analyses (Voight and colleagues, 2012) used a genetic variant that raises HDL and found carriers had no lower risk of heart attack — evidence that some HDL-raising mechanisms do not lower risk, so raising HDL cannot be assumed to reduce it.
Verification¶
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Registry ID ref:76b98cd11cf8 · see in the full table