Haldane's Sieve and Adaptation From the Standing Genetic Variation¶
Orr, & Betancourt. (2001). Haldane's Sieve and Adaptation From the Standing Genetic Variation. Genetics.
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Domain-specific¶
- Haldane's Sieve
- The consequence for the observable genetic architecture of adaptation is systematic: the alleles that actually fix and produce the signature of a selective sweep in population-genomic data are enriched for dominant phenotypic effects relative to the underlying distribution of beneficial mutations generated by the mutation process
This sourceThe definition of Haldane's sieve as a bias against establishment of new recessive beneficial mutations, which makes alleles fixed from new mutation dominance-biased. The result that alleles fixed from mutation–selection balance after an environmental change have fixation probabilities generally independent of dominance, so Haldane's sieve does not hold for adaptation from standing variation.
Supported in partVerified against the source
- The consequence for the observable genetic architecture of adaptation is systematic: the alleles that actually fix and produce the signature of a selective sweep in population-genomic data are enriched for dominant phenotypic effects relative to the underlying distribution of beneficial mutations generated by the mutation process
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