FSRH Clinical Guideline: Drug Interactions with Hormonal Contraception¶
Faculty of Sexual and Reproductive Healthcare. (2017). FSRH Clinical Guideline: Drug Interactions with Hormonal Contraception: Drug Interactions with Hormonal Contraception.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Enzyme Induction
- Because CYP3A4 also metabolizes ethinylestradiol, a woman on a combined oral contraceptive who starts rifampicin has her contraceptive steroid cleared faster, its plasma level falls, and breakthrough ovulation and contraceptive failure can result — a well-documented interaction that leads guidelines to recommend an additional non-hormonal method
This sourceThat guidance on enzyme-inducing drugs and hormonal contraception recommends an additional or alternative non-hormonal method when rifampicin is taken with a combined oral contraceptive.
- Because CYP3A4 also metabolizes ethinylestradiol, a woman on a combined oral contraceptive who starts rifampicin has her contraceptive steroid cleared faster, its plasma level falls, and breakthrough ovulation and contraceptive failure can result — a well-documented interaction that leads guidelines to recommend an additional non-hormonal method
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