The 'Cytokine Storm'¶
Karki, R., & Kanneganti, T. (2021). The 'Cytokine Storm': Molecular Mechanisms and Therapeutic Prospects. Trends in Immunology, 42(8), 681-705.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Cycle
- The transferable content of the cycle is a set of diagnostics and interventions that carry across substrates because each attaches to the closed-loop skeleton rather than to any kind of network, and the skeleton recurs with consistent structural consequences from combinatorics through control, computer science, economics, biology, hermeneutics, politics, and topology. Cycle inventory transfers into the diagnosis of complex systems: an analyst trained to list and sign the cycles of a feedback diagram carries a diagnostic that ports to ecology (predator–prey cycles), macroeconomics (debt cycles), organizational dynamics (blame cycles), and climate (carbon-cycle perturbations), the same move in each. Acyclicity transfers as a design discipline: the software practice of forbidding circular module dependencies ports to organizational design (no circular reporting), causal modelling (directed acyclic graphs), and argumentation (no circular reasoning), because the structural insight — cycles obstruct decomposition and ordering — is substrate-free. Cycle-breaking interventions transfer broadly: a cycle once identified can be broken by removing or weakening any single edge, and the vocabulary — break the cycle, dampen the loop gain, decouple the variables — transfers from systems dynamics to debt restructuring to addiction recovery to inflammatory disease, where a positive cytokine cycle drives runaway pathology.
This sourceDescribes the self-amplifying positive feedback loop between cytokine signaling and inflammatory cell death that drives a cytokine storm, and therapeutic strategies that interrupt the loop.
Supported in partVerified against the work's full text
The review documents a self-amplifying cytokine feedback loop that drives pathology and drugs that interrupt it; it does not address single-edge cycle-breaking or other domains.
“involved in a positive feedback loop whereby cytokine signaling or PAMP/DAMP sensing causes inflammatory cell death that facilitates further pathogenic cytokine release, culminating in a CS to drive severe, life-threatening damage”
- The transferable content of the cycle is a set of diagnostics and interventions that carry across substrates because each attaches to the closed-loop skeleton rather than to any kind of network, and the skeleton recurs with consistent structural consequences from combinatorics through control, computer science, economics, biology, hermeneutics, politics, and topology. Cycle inventory transfers into the diagnosis of complex systems: an analyst trained to list and sign the cycles of a feedback diagram carries a diagnostic that ports to ecology (predator–prey cycles), macroeconomics (debt cycles), organizational dynamics (blame cycles), and climate (carbon-cycle perturbations), the same move in each. Acyclicity transfers as a design discipline: the software practice of forbidding circular module dependencies ports to organizational design (no circular reporting), causal modelling (directed acyclic graphs), and argumentation (no circular reasoning), because the structural insight — cycles obstruct decomposition and ordering — is substrate-free. Cycle-breaking interventions transfer broadly: a cycle once identified can be broken by removing or weakening any single edge, and the vocabulary — break the cycle, dampen the loop gain, decouple the variables — transfers from systems dynamics to debt restructuring to addiction recovery to inflammatory disease, where a positive cytokine cycle drives runaway pathology.
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