On Schemes of Combinatorial Transcription Logic.¶
Buchler, N. E., Gerland, U., & Hwa, T. (2003). On Schemes of Combinatorial Transcription Logic. Proceedings of the National Academy of Sciences, 100(9), 5136-5141.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Population Coding
- Gene regulation — many transcription factors with broad, overlapping affinities jointly determine expression states, with no single factor encoding "the state."
This sourceShows how multiple transcription factors with overlapping affinities jointly implement combinatorial gene-regulatory logic.
Supported in partVerified against the work's full text
The paper shows multiple transcription factors jointly set a gene's output, but via specific DNA sites and weak protein contacts, not broad overlapping affinities forming a population code.
“In eukaryotes, each node can be regulated combinatorially, often by four to five other nodes”
- Gene regulation — many transcription factors with broad, overlapping affinities jointly determine expression states, with no single factor encoding "the state."
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