Somatic Generation of Antibody Diversity.¶
Tonegawa, S. (1983). Somatic Generation of Antibody Diversity. Nature, 302(5909), 575-581.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Sparse Coding
- The capacity-by-combinatorics argument is the whole point: a finite genome cannot encode a dedicated detector for every possible pathogen, so the body generates a huge diverse pool by combinatorial gene rearrangement (V(D)J recombination) and lets each antigen select its matching few.
This sourceEstablishes V(D)J recombination as the combinatorial gene-rearrangement mechanism generating the huge diverse antigen-receptor pool — the combinatorial capacity argument made molecular.
Supported in partVerified against the publisher's abstract
The abstract backs only the combinatorial half: somatic recombination and mutation greatly increase the diversity of antibody one organism makes; it says nothing of genome-capacity arguments or antigen-driven selection.
“Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.”
- The capacity-by-combinatorics argument is the whole point: a finite genome cannot encode a dedicated detector for every possible pathogen, so the body generates a huge diverse pool by combinatorial gene rearrangement (V(D)J recombination) and lets each antigen select its matching few.
Verification¶
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Registry ID ref:7d6a6dd8fcf5 · see in the full table