Somatic Generation of Antibody Diversity.¶
Tonegawa, S. (1983). Somatic Generation of Antibody Diversity. Nature, 302(5909), 575-581.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Sparse Coding
- The capacity-by-combinatorics argument is the whole point: a finite genome cannot encode a dedicated detector for every possible pathogen, so the body generates a huge diverse pool by combinatorial gene rearrangement (V(D)J recombination) and lets each antigen select its matching few.
This sourceEstablishes V(D)J recombination as the combinatorial gene-rearrangement mechanism generating the huge diverse antigen-receptor pool — the combinatorial capacity argument made molecular.
- The capacity-by-combinatorics argument is the whole point: a finite genome cannot encode a dedicated detector for every possible pathogen, so the body generates a huge diverse pool by combinatorial gene rearrangement (V(D)J recombination) and lets each antigen select its matching few.
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Registry ID ref:7d6a6dd8fcf5 · see in the full table