How to improve R&D productivity¶
Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R., & Schacht, A. L. (2010). How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Reviews Drug Discovery, 9(3), 203-214.
Cited by¶
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Primes¶
- Anna Karenina Principle
- In drug development, a molecule must pass potency, selectivity, safety, manufacturability, pharmacokinetics, market need, and regulatory approval; the attrition curve is the pattern made quantitative.
This sourceDocuments the staged-attrition drug pipeline and the low survival rate of small-molecule candidates from discovery to approval as the conjunctive-necessity pattern made quantitative.
- In drug development, a molecule must pass potency, selectivity, safety, manufacturability, pharmacokinetics, market need, and regulatory approval; the attrition curve is the pattern made quantitative.
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