SOME QUANTITATIVE USES OF DRUG ANTAGONISTS¶
Arunlakshana, & Schild. (1959). SOME QUANTITATIVE USES OF DRUG ANTAGONISTS.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Pharmacodynamic Antagonism
- The clinician classifies the opposition — competitive, non-competitive, functional/physiological, or chemical — and reads off whether "give more agonist" is viable: competitive antagonism shifts the dose-response curve rightward while preserving the achievable maximum, so the reasoner predicts escalation can recover the effect (and applies Schild-plot / dose-ratio analysis to quantify how far the curve has shifted and confirm the competitive mode)
This sourceThe source paper of the pA(x) measurement method for testing competitive versus noncompetitive antagonism.
Supported in partVerified against the publisher's abstract
“Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law.”
- The clinician classifies the opposition — competitive, non-competitive, functional/physiological, or chemical — and reads off whether "give more agonist" is viable: competitive antagonism shifts the dose-response curve rightward while preserving the achievable maximum, so the reasoner predicts escalation can recover the effect (and applies Schild-plot / dose-ratio analysis to quantify how far the curve has shifted and confirm the competitive mode)
Verification¶
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Registry ID ref:7fc4e1e85a3e · see in the full table