Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type¶
Bi, G., & Poo, M. (1998). Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type. The Journal of Neuroscience.
Cited by¶
2 citations across 2 artifacts.
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Domain-specific¶
- Spike-Timing-Dependent Plasticity
- Spike-timing-dependent plasticity (STDP) is the synaptic learning rule in which the direction and magnitude of long-lasting change in synaptic efficacy are determined by the relative timing — on a millisecond scale — of presynaptic and postsynaptic action potentials: when the presynaptic spike precedes the postsynaptic spike within a window of a few tens of milliseconds, the synapse is potentiated (LTP), most strongly at the shortest intervals
This sourceThe systematic spike-timing pairing study in dissociated cultured rat hippocampal neurons. The order-sensitive potentiation and depression measured between pairs of dissociated cultured hippocampal neurons. The defining pairing experiment in dissociated cultured hippocampal neurons, which mapped potentiation within about 20 ms of pre-before-post spiking and depression within about 20 ms of post-before-pre spiking.
SupportedVerified against the source
- Spike-timing-dependent plasticity (STDP) is the synaptic learning rule in which the direction and magnitude of long-lasting change in synaptic efficacy are determined by the relative timing — on a millisecond scale — of presynaptic and postsynaptic action potentials: when the presynaptic spike precedes the postsynaptic spike within a window of a few tens of milliseconds, the synapse is potentiated (LTP), most strongly at the shortest intervals
- Synaptic Plasticity
- Spike-timing-dependent plasticity (STDP) refines this by making the sign of change contingent on the millisecond-scale temporal order of presynaptic and postsynaptic spikes
This sourceBi and Poo's study found that the relative timing of presynaptic and postsynaptic spiking determined the direction and extent of synaptic change, with a 20 msec window separating potentiation from depression, and suggested Hebb's rule be extended to incorporate spike timing.
SupportedVerified against the publisher's abstract
“suggest that Hebb's rule may need to incorporate a quantitative consideration of spike timing that reflects the narrow and asymmetric window for the induction of synaptic modification.”
- Spike-timing-dependent plasticity (STDP) refines this by making the sign of change contingent on the millisecond-scale temporal order of presynaptic and postsynaptic spikes
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