Funnels, Pathways, and the Energy Landscape of Protein Folding¶
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995). Funnels, Pathways, and the Energy Landscape of Protein Folding: A Synthesis. Proteins: Structure, Function, and Bioinformatics, 21(3), 167-195.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Optimization Landscape
- The topology-to-behaviour invariant is what makes this more than description — the funnel topology predicts that the folding search will succeed by ordinary downhill dynamics without needing to enumerate the astronomically many conformations (the resolution of Levinthal's paradox), because the surface itself channels the search.
This sourceFunnel landscape resolving Levinthal's paradox by channeling the folding search downhill.
- The topology-to-behaviour invariant is what makes this more than description — the funnel topology predicts that the folding search will succeed by ordinary downhill dynamics without needing to enumerate the astronomically many conformations (the resolution of Levinthal's paradox), because the surface itself channels the search.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:823020aa86ad · see in the full table