Funnels, Pathways, and the Energy Landscape of Protein Folding¶
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995). Funnels, Pathways, and the Energy Landscape of Protein Folding: A Synthesis. Proteins: Structure, Function, and Bioinformatics, 21(3), 167-195.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Optimization Landscape
- The topology-to-behaviour invariant is what makes this more than description — the funnel topology predicts that the folding search will succeed by ordinary downhill dynamics without needing to enumerate the astronomically many conformations (the resolution of Levinthal's paradox), because the surface itself channels the search.
This sourceFunnel landscape resolving Levinthal's paradox by channeling the folding search downhill.
Supported in partVerified against the publisher's abstract
The abstract states that the energy-landscape approach explains why folding pathways occur, which is the frame of the funnel claim, but it says nothing about Levinthal's paradox or downhill search.
“The statistical energy landscape approach explains when and why unique behaviors, such as specific folding pathways, occur in some proteins and more generally explains the distinction between folding processes common to all sequences and those peculiar to individual sequences.”
- The topology-to-behaviour invariant is what makes this more than description — the funnel topology predicts that the folding search will succeed by ordinary downhill dynamics without needing to enumerate the astronomically many conformations (the resolution of Levinthal's paradox), because the surface itself channels the search.
Verification¶
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Registry ID ref:823020aa86ad · see in the full table