Neocortical Excitation/Inhibition Balance in Information Processing and Social Dysfunction¶
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., et al. (2011). Neocortical Excitation/Inhibition Balance in Information Processing and Social Dysfunction. Nature, 477, 171-178.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Excitation-Inhibition Balance
- Neuroscience (canonical): cortical activity at every scale shows close balance of glutamatergic excitation and GABAergic inhibition; loss of balance produces epilepsy (excitation runaway) or silence, and is implicated in autism, schizophrenia, and anxiety.
This sourceEstablishes the cortical E/I balance of glutamatergic excitation and GABAergic inhibition, its high-gain processing role, and the link of imbalance to epilepsy and social/cognitive dysfunction.
Supported in partVerified against the work's full text
The paper supports the autism and schizophrenia link to elevated E/I balance, but not epilepsy-or-silence as outcomes of imbalance, anxiety, or balance at every scale.
“Several lines of evidence have indicated the involvement of elevated cellular E/I balance in the aetiology of medication-unresponsive social and information-processing impairments in autism and schizophrenia”
- Neuroscience (canonical): cortical activity at every scale shows close balance of glutamatergic excitation and GABAergic inhibition; loss of balance produces epilepsy (excitation runaway) or silence, and is implicated in autism, schizophrenia, and anxiety.
Verification¶
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