The pharmacogenetics of codeine hypoalgesia¶
Sindrup, & Br??sen. (1995). The pharmacogenetics of codeine hypoalgesia.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- First-Pass Metabolism
- Codeine itself has minimal analgesic activity; CYP2D6 in the liver converts it to morphine, making codeine a prodrug whose efficacy depends entirely on first-pass conversion.
This sourcePharmacogenetics review reporting that codeine's hypoalgesic effect depends on CYP2D6-catalysed O-demethylation to morphine, absent in poor metabolisers and in quinidine-blocked extensive metabolisers.
Supported in partVerified against the publisher's abstract
“Lack of influence of codeine on experimental pain in PM as well as in EM treated with the CYP2D6 blocker quinidine, who are both practically unable to convert codeine to morphine, has supported an old hypothesis that codeine acts through metabolically formed morphine.”
- Codeine itself has minimal analgesic activity; CYP2D6 in the liver converts it to morphine, making codeine a prodrug whose efficacy depends entirely on first-pass conversion.
Verification¶
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Registry ID ref:85a417e57ae0 · see in the full table