Thymic Development of Gut-Microbiota-Specific T Cells.¶
Zegarra-Ruiz, D. F., Kim, D. V., Norwood, K., Kim, M., Wu, W. H., Saldana-Morales, F. B., Hill, A. A., et al. (2021). Thymic Development of Gut-Microbiota-Specific T Cells. Nature, 413-417.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Critical Period
- Immunology and microbiome: thymic education of T-cells occurs in a narrow developmental window that thymic involution closes; gut-microbiome installation has a critical window in the first years that shapes lifelong immune phenotype.
This sourceShows microbial antigens are trafficked to the thymus in an early-life window to shape the T-cell repertoire, and that perturbations of early gut microbiota persist into adulthood — supporting a developmental immune-installation window; thymic involution later closes thymic output.
Supported in partVerified against the work's full text
Shows microbiota-specific thymic T-cell expansion occurs in young but not adult mice, i.e. an early-life window; does not discuss thymic involution or lifelong phenotype.
“including how to reopen the development window and restart the thymic generation of bacteria-specific T cells in older hosts”
- Immunology and microbiome: thymic education of T-cells occurs in a narrow developmental window that thymic involution closes; gut-microbiome installation has a critical window in the first years that shapes lifelong immune phenotype.
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