Estimation of population characteristics of pharmacokinetic parameters from routine clinical data

Sheiner, L. B., Rosenberg, & Marathe, V. V. (1977). Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. Journal of Pharmacokinetics and Biopharmaceutics, 5(5), 445-479.

Type

Journal article

Intellectual base

Primary research

Year

1977

Link

https://doi.org/10.1007/bf01061728verified

Cited from

pharmacology_toxicology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
  • The resolution requires either therapeutic drug monitoring (empirical data on that patient's concentration) or prospective Bayesian adjustment of dose based on pre-specified covariates (renal function, weight, genetic markers).

    This sourceIntroduces Bayesian individualization of PK parameters from sparse clinical observations; foundation of therapeutic drug monitoring and individualized dosing under population-vs-individual tension.

Verification

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Registry ID ref:86f06749ea15 · see in the full table