Lethality and Centrality in Protein Networks.

Jeong, H., Mason, S. P., Barabási, A. -., & Oltvai, Z. N. (2001). Lethality and Centrality in Protein Networks. Nature, 411(6833), 41-42.

Type

Journal article

Intellectual base

Primary research

Year

2001

Volume

411

Issue

6833

Pages

41-42

DOI

10.1038/35075138

DOI registrant

Springer Nature

Link

https://doi.org/10.1038/35075138

Cited from

computer_science

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Single Point of Failure
  • In biology, hub genes and hub proteins whose loss disrupts wide networks, and a single artery feeding a critical region, play the same role.

    This sourceShows that highly connected 'hub' proteins are disproportionately essential — the molecular-biology hub whose loss disrupts wide networks.

    Supported in partVerified against the work's full text

    Shows that highly connected yeast proteins are far more often essential; supports the hub-protein half only, not hub genes broadly or the arterial analogy.

    “As shown in Fig. 1c, the likelihood that removal of a protein will prove lethal clearly correlates with the number of interactions the protein has.”

    Read by an automated reader; not a human review. How support was checked

Verification

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