Basic & Clinical Pharmacology¶
Katzung, B. G., & Trevor, A. J. (2018). Basic & Clinical Pharmacology. McGraw-Hill Education.
Cited by¶
5 citations across 5 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Therapeutic Window
- As Katzung and Trevor (2017) underscore in their treatment of pharmacodynamics and dose-response analysis, several common misclassifications muddle the therapeutic-window construct.
This sourceStandard pharmacology textbook: chapter on pharmacodynamics develops graded vs quantal dose-response curves and clarifies common misclassifications of efficacy, potency, safety range, and therapeutic index.
- As Katzung and Trevor (2017) underscore in their treatment of pharmacodynamics and dose-response analysis, several common misclassifications muddle the therapeutic-window construct.
Mechanisms¶
- Clinical Treatment Adjustment
- Every drug has a therapeutic window between too little and too much, and adjustments that optimize a target without respecting that window and the whole-patient picture trade a good chart for a worse patient.
This sourceDefines the therapeutic window as the dose range between insufficient effect and unacceptable toxicity.
- Every drug has a therapeutic window between too little and too much, and adjustments that optimize a target without respecting that window and the whole-patient picture trade a good chart for a worse patient.
- Competitive Occupancy Inhibition
- A large enough surge of activator overwhelms the occupancy and the pathway breaks through, so competitive inhibition is the wrong choice when the drive can spike without limit and the block must hold regardless.
This sourceCompetitive inhibition is surmountable by sufficiently increasing agonist concentration, so it cannot provide a drive-independent block.
- A large enough surge of activator overwhelms the occupancy and the pathway breaks through, so competitive inhibition is the wrong choice when the drive can spike without limit and the block must hold regardless.
- Physiological Regulation Protocol
- - A window with two edges. Correction aims to keep the variable between an under-effect floor and a toxicity ceiling, not merely above or below one line — the safe band is bounded on both sides.
This sourceDefines the therapeutic window as the usable dose range between a minimum therapeutic dose and a minimum toxic dose.
- - A window with two edges. Correction aims to keep the variable between an under-effect floor and a toxicity ceiling, not merely above or below one line — the safe band is bounded on both sides.
- Pulse Dosing
- Its strength is sustaining effect while limiting cumulative burden: by spacing strong pulses with recovery gaps it evades tachyphylaxis — the rapid tolerance a system develops to constant stimulation — so a given input keeps working over a long horizon at far lower total exposure.
This sourceTachyphylaxis is a rapidly developing diminution of response during continued or repeated stimulation.
- Its strength is sustaining effect while limiting cumulative burden: by spacing strong pulses with recovery gaps it evades tachyphylaxis — the rapid tolerance a system develops to constant stimulation — so a given input keeps working over a long horizon at far lower total exposure.
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