Drug Repurposing

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., et al. (2019). Drug Repurposing: Progress, Challenges and Recommendations. Nature Reviews Drug Discovery, 18(1), 41-58.

Type

Journal article

Intellectual base

Primary research

Year

2019

Volume

18

Issue

1

Pages

41-58

DOI

10.1038/nrd.2018.168

DOI registrant

Springer Nature

Link

https://doi.org/10.1038/nrd.2018.168

Cited from

organizational_management

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Adaptive Redirection
  • In pharmaceutical development the channel is a safety database, a manufacturing and stability package, and a validated assay, and a compound that fails in one indication carries all three into another.

    This sourceDocuments that repurposed compounds are de-risked by existing safety, pharmacokinetic and formulation/manufacturing packages and can therefore enter development at a later phase, with shorter timelines and lower cost than a fresh programme.

    Supported in partVerified against the publisher's abstract

    The review's abstract supports de-risking repurposed compounds with lower cost and shorter timelines, but not the claim's three-item channel list or its cross-indication carry-over.

    “repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines”

    Read by an automated reader; not a human review. How support was checked

Domain-specific

• Drug Repositioning
  • Identification is only the beginning: a predicted drug–disease link must survive mechanistic, preclinical, clinical, regulatory, manufacturing, safety, and commercial evaluation.

Verification

Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.

Does it back the claim? Read against the text for 1 of 2 citations: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.

Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.

See how references were verified.

Registry ID ref:92eab5c1cc12 · see in the full table