A History of Cancer Chemotherapy.¶
DeVita, V. T., & Chu, E. (2008). A History of Cancer Chemotherapy. Cancer Research, 68(21), 8643-8653.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Intervention-Coupled Harm
- For coupled harms, the combination move exploits that if mechanism A yields benefit with harm signature H_A and mechanism B yields benefit with harm signature H_B, combining at sub-maximal doses can achieve full benefit while keeping each harm signature below threshold — used in combination chemotherapy, defence-in-depth, and combination antibiotics.
This sourceEstablishes that cytotoxic chemotherapy kills rapidly dividing cancer cells and rapidly dividing normal cells (marrow, gut, follicles) by the identical division-targeting mechanism, and the rationale for combination chemotherapy at sub-maximal doses.
Supported in partVerified against the work's full text
DeVita and Chu show combination chemotherapy outperformed single agents, but not that sub-maximal doses keep each drug's harm below threshold.
“Finally, combinations of drugs, an anathema in medicine at the time, were superior to single agents.”
- For coupled harms, the combination move exploits that if mechanism A yields benefit with harm signature H_A and mechanism B yields benefit with harm signature H_B, combining at sub-maximal doses can achieve full benefit while keeping each harm signature below threshold — used in combination chemotherapy, defence-in-depth, and combination antibiotics.
Verification¶
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Registry ID ref:982164f135ff · see in the full table