A Multiple Testing Procedure for Clinical Trials.

O'Brien, P. C., & Fleming, T. R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549-556.

Type

Journal article

Intellectual base

Primary research

Year

1979

DOI

10.2307/2530245

Link

https://doi.org/10.2307/2530245

Cited from

economics_finance

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Optimal Stopping Rule
  • Designers compute boundaries (O'Brien–Fleming, Pocock) that spend the total error budget across looks so that the cumulative false-positive rate stays controlled despite repeated peeking.

    This sourceIntroduces the O'Brien–Fleming group-sequential boundary that spends the total error budget across repeated interim looks while controlling the cumulative false-positive rate.

Verification

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Registry ID ref:98c1c806c020 · see in the full table