Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports¶
Evans, W., Waller, P. C., & Davis, S. (2001). Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports. Pharmacoepidemiology and Drug Safety.
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Domain-specific¶
- Adverse Drug Event
- Clinical practice — the bedside home, daily use in prescribing, dispensing, and monitoring, weighing the benefit-to-harm margin for this patient, at this dose, in this co-medication context. Pharmacovigilance and post-market surveillance — the dedicated discipline, where spontaneous-reporting systems (FAERS, Yellow Card, the Uppsala data) and disproportionality/Bayesian signal detection surface above-background (drug, event) pairs
This sourceThe proportional reporting ratio as a signal-generation tool, developed and validated on the UK Yellow Card spontaneous-reporting database; the Bayesian methods and the other reporting systems named alongside it are elsewhere.
- Clinical practice — the bedside home, daily use in prescribing, dispensing, and monitoring, weighing the benefit-to-harm margin for this patient, at this dose, in this co-medication context. Pharmacovigilance and post-market surveillance — the dedicated discipline, where spontaneous-reporting systems (FAERS, Yellow Card, the Uppsala data) and disproportionality/Bayesian signal detection surface above-background (drug, event) pairs
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