Pharmacokinetics¶
Gibaldi, M., & Perrier, D. (1982). Pharmacokinetics.
Cited by¶
7 citations across 7 artifacts.
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Primes¶
- Accumulation
- And in pharmacology, drug stock in the bloodstream accumulates from absorption minus clearance, with chronic regimens designed around the convergence of stock to a steady state under constant flow.
This sourceStandard pharmacokinetics reference deriving plasma drug concentration as the integral of absorption minus clearance and the convergence of drug stock to a steady state under repeated dosing — the half-life logic of chronic regimens. (Book; no DOI — ISBN 9780824710422.)
- And in pharmacology, drug stock in the bloodstream accumulates from absorption minus clearance, with chronic regimens designed around the convergence of stock to a steady state under constant flow.
- Bioaccumulation
- At high chronic exposures or when metabolic elimination becomes saturated, kinetics may shift to zero-order (constant elimination rate regardless of dose) or show Michaelis-Menten kinetics — a regime Gibaldi and Perrier (1982) treat in detail in their canonical compartmental-modeling exposition of pharmacokinetics.
This sourceMarcel Dekker. Standard reference developing compartmental models and saturable (Michaelis-Menten / zero-order) elimination kinetics
- At high chronic exposures or when metabolic elimination becomes saturated, kinetics may shift to zero-order (constant elimination rate regardless of dose) or show Michaelis-Menten kinetics — a regime Gibaldi and Perrier (1982) treat in detail in their canonical compartmental-modeling exposition of pharmacokinetics.
- Dose-Response Relationship
- The construct manages the complexity of input-output mappings in systems by parameterizing them: rather than describing the entire response surface case-by-case, a fitted functional form summarizes the mapping in a few interpretable parameters (ED50, slope, Emax, threshold), in the spirit of the parameter-based pharmacokinetic-pharmacodynamic compression formalized by Gibaldi and Perrier (1982).
This sourceMarcel Dekker. Standard pharmacokinetics reference developing compartmental models that compress absorption-distribution-elimination kinetics into a few interpretable parameters; supports D47-027 (parameter-based PK/PD compression paralleling dose-response parameterization).
- The construct manages the complexity of input-output mappings in systems by parameterizing them: rather than describing the entire response surface case-by-case, a fitted functional form summarizes the mapping in a few interpretable parameters (ED50, slope, Emax, threshold), in the spirit of the parameter-based pharmacokinetic-pharmacodynamic compression formalized by Gibaldi and Perrier (1982).
- PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
- The full model is a composition, in the formalism systematized by Gibaldi and Perrier (1982): dose D input → PK model → time course of plasma or effect-site concentration C(t) → PD model → time course of effect E(t).
This sourceMarcel Dekker. Standard pharmacokinetics reference: develops compartmental models that compress complex absorption-distribution-elimination kinetics into a small number of interpretable parameters, paralleling the parameterization that dose-response curves achieve for input-output relationships.
- The full model is a composition, in the formalism systematized by Gibaldi and Perrier (1982): dose D input → PK model → time course of plasma or effect-site concentration C(t) → PD model → time course of effect E(t).
- Reservoir-Flux Network
- Pharmacokinetics. Compartmental PK/PD models represent the body as one to three reservoirs with first-order rate constants between them and to elimination; drug mass is conserved minus elimination.
This sourceCanonical text on one- and multi-compartment models with first-order rate constants and conserved drug mass minus elimination.
- Pharmacokinetics. Compartmental PK/PD models represent the body as one to three reservoirs with first-order rate constants between them and to elimination; drug mass is conserved minus elimination.
- Signal Decay and Fadeout
- Half-life determines dosing intervals; multiple doses must account for decay of prior doses, as Gibaldi and Perrier (1982) detail in the canonical pharmacokinetics treatment of multi-dose plasma-level superposition.
This sourceMarcel Dekker. Standard pharmacokinetics reference: develops compartmental models that compress complex absorption-distribution-elimination kinetics into a small number of interpretable parameters, paralleling the parameterization that dose-response curves achieve for input-output relationships.
- Half-life determines dosing intervals; multiple doses must account for decay of prior doses, as Gibaldi and Perrier (1982) detail in the canonical pharmacokinetics treatment of multi-dose plasma-level superposition.
Domain-specific¶
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