Cross-over Trials in Clinical Research

Senn, S. (2002). Cross-over Trials in Clinical Research. Wiley.

Type

Book

Intellectual base

Textbook

Year

2002

DOI

10.1002/0470854596

ISBN

9780471496533

Link

https://doi.org/10.1002/0470854596

Cited from

philosophy

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Washout Failure
  • In clinical trials, crossover designs require a drug washout between treatments; too short, and the second arm's effect estimate is biased by residual pharmacology.

    This sourceStandard reference on crossover designs: carryover, setting the washout interval relative to pharmacological half-life, and the bias of too-short washouts on second-period estimates.

Mechanisms

• Residual Tail Washout Check
  • The carryover effect

    This sourceDefines carryover as a residual treatment effect that persists after treatment has ceased.

Verification

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Links previously used in the corpus

Before the registry existed this work was also linked 1 other way.

• https://onlinelibrary.wiley.com/doi/book/10.1002/0470854596 ×1

Registry ID ref:9b467ab2fe69 · see in the full table